Duke Collaborative Influenza Vaccine Innovation Centers

A national effort to develop a longer-lasting, more broadly protective vaccine to replace seasonal flu shots

The Duke Human Vaccine Institute (DHVI) was selected to join the Collaborative Influenza Vaccine Innovation Centers (CIVICs) in all three components of the research program, which is funded by the National Institute of Allergic and Infectious Diseases (NIAID) through The Division of Microbiology and Infectious Diseases (DMID). The CIVICs program aims To improve the durability of seasonal influenza vaccines and develop a universal influenza vaccine through iterative vaccine design, pre-clinical animal studies, and early phase clinical trials.

The Duke CIVICS Program consists of multidisciplinary teams of investigators and their collaborators to support the research objectives laid out by the NIAID to design, manufacture, and test novel influenza vaccine candidates.

Vaccine Design & Development

Vaccine Design
Immunological Analyses
Assay & Reagent Core

Vaccine Manufacturing

Good Manufacturing Facility
Protein Production Facility

Clinical Studies

Vaccine & Trials Unit
Challenge Unit
Biorepository

Leadership

The Duke CIVICs Leadership team has extensive experience in vaccine design through projects such as the Center for HIV/AIDS Vaccine Immunology , the Defense Advanced Research Projects Agency (DARPA) Pandemic Prevention Platform (P3), and in a Boston Children’s Hospital-based P01 grant focused on structural studies of B cell repertoires induced by influenza infection and vaccination.

Back row (L to R): Mr. Chris Todd, Dr. Georgia Tomaras, Dr. Gregory Sempowski, Dr. Tony Moody, Dr. Thomas Denny, Ms. Hilary Bouton-Verville, Dr. Nicholas Heaton Front row (L to R): Dr. Matt Johnson, Dr. Chip Walter.

Goals

· Be at least 75% effective against symptomatic influenza virus infection

  1. · Protect against group I and group II influenza A viruses

  2. · Provide durable protection that lasts at least one year and preferably through multiple influenza seasons

  3. · Be suitable for all age groups

Network